Programma/abstracts Papendal 1998



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Wednesday, November 18, 2015



12.00-13.00

Registration + lunch





SESSION I

Chair: xx











13.00-13.10

Response to treatment with bisphosphonates in polyostotic fibrous dysplasia and McCune Albright syndrome: A case series

Natasha Appelman-Dijkstra1, Bas Majoor2, Sander Dijkstra2, Neveen A.T. Hamdy

Center for Bone Quality Leiden University Medical Center



1 Department of Medicine: Division of Endocrinology, 2Department of Orthopaedic Surgery

p. 14










13.10-13.20

Osteogenesis and Osteoclastogenesis by Periodontal Ligament Fibroblasts From Patients with Fibrodysplasia Ossificans Progressiva

Teun J. de Vries1, Ton Schoenmaker1, Dimitra Micha2, Coen Netelenbos3, Gerard Pals2, E. Marelise W. Eekhoff3, Nathalie Bravenboer3

1Periodontology, ACTA, UvA and VU University, MOVE Research Institute, 2Clinical genetics and 3Endocrinology, VUmc, Amsterdam, The Netherlands.

p. 14










13.20-13.30

In-Vitro Models of Devitalized Extracellular Matrix to Modulate the Osteogenic Potential of Mesenchymal Stromal Cells

Marta Baroncelli1, Rodrigo Alves1, Jeroen Demmers2, Jeroen van de Peppel1, Hans van Leeuwen1

1Erasmus MC, Internal Medicine, 2Erasmus MC, Proteomics Center

p. 15










13.30-13.40

Association between bone marrow adiposity and bone turnover before and after raloxifene

Kerensa Beekman1, Martin den Heijer1, Mario Maas2, Peter Bisschop3, Nathalie Bravenboer4

1VUmc, Endocrinology, 2AMC, Radiology, 3AMC, Endocrinology and Metabolism, 4VUmc, Clinical Chemistry.













13.40-13.50

A diverse stimulatory role of IL-1β on different murine osteoclast precursor subsets: a time-lapse microscopy study

Yixuan Cao1, Ineke Jansen2, Sara Sprangers1, Jan Stap3, Vincent Everts1, Teun J. de Vries2

1Department of Oral Cell Biology and 2Periodontology, ACTA, UvA and VU University, Amsterdam, MOVE Research Institute; 3Van Leeuwenhoek Center for Advanced Microscopy, AMC, UvA, Amsterdam, The Netherlands












13.50-14.00

Reproducibility of a semi‑automatic algorithm to assess bone attenuation and thoracic kyphosis on chest CT scans of patients with chronic obstructive pulmonary disease

Mayke van Dort1, Erica Rutten2, Bert van Rietbergen3, Elisabeth Romme4, Frank Smeenk4, Piet Geusens1, Emiel Wouters5, Joop van den Bergh1,6

1 Department of Internal Medicine, MUMC; 2 Research and Education, Centre of expertise for chronic organ failure;

3 Department of Medical Engineering, TU/e; 4 Department of Respiratory Medicine, Catharina Hospital; 5 Department of Respiratory Medicine, MUMC; 6 Department of Internal Medicine, VieCuri Medical Centre













14.00-14.10

Maternal TRPV6 is Crucial for Early Bone Development

Bram van der Eerden1, Petra Weissgerber2, Marijke Schreuders-Koedam1, Cindy van der Leije1, Marc Freichel3, Johannes van Leeuwen1, Veit Flockerzi2.

1 Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands

2 Institute for Pharmacology and Toxicology, University of Saarland, Homburg, Germany

3 Pharmacological Institute, University of Heidelberg, Heidelberg, Germany













14.10-14.20

Assessment of Bone Material Strength index by Reference Point Indentation in patients with acromegaly

Frank Malgo1, Neveen A.T. Hamdy1, Alberto M. Pereira2, Nienke R. Biermasz2, Natasha M. Appelman-Dijkstra1

1Department of Internal Medicine: Section of Endocrinology and Center for Bone Quality, 2Department of Internal Medicine: Section of Endocrinology and Center for Endocrine Tumours, Leiden University Medical Center, Leiden













14.20-14.30

The association between glucose metabolism status and a history of falls or fractures – The Maastricht Study

Ellis de Waard1, Annemarie Koster2, Tom Melai3, Tineke van Geel4, Ronald Henry1, Miranda Schram1, Pieter Dagnelie5, Carla van der Kallen1, Simone Sep1, Coen Stehouwer1, Nicolaas Schaper1, Hans Savelberg3, Piet Geusens1, Joop van den Bergh1,6

1MUMC+, Internal Medicine, 2UM, Social Medicine,

3UM, Human Movement Science, 4UM, Family Medicine, 5UM, Epidemiology, 6VieCuri, Internal Medicine, the Netherlands.













14.30-15.00


Coffee/Tea break

SESSION II

Chair:





15.00-15.50

Key-note lecture:

The bone-vascular axis, lessons from chronic kidney disease Prof Dr P Evenpoel



Laboratory of Nephrology Department of Immunology and Microbiology, UZ Leuven, Belgium




15.50-16.00

Osteoporosis and Fractures among Residents with Dementia in Nursing Homes: Which Residents have the Greatest Risk for Fractures?

Rutger L. van Bezooijen1,2, Victor G.M. Chel,1 Natasha M. Appelman-Dijkstra,3 Neveen A.T. Hamdy,3 Wilco P. Achterberg1

1Public Health and Primary Care, LUMC, 2Florence Health and Care, The Hague, 3Endocrinology, LUMC

p. 18










16.00-16.10

Bone Substrate Dictates Early Commitment of Different Human Osteoclast Precursors

Sara Sprangers1, Ton Schoenmaker1,2, Yixuan Cao1, Vincent Everts1, Teun J. de Vries1,2

1Oral Cell Biology and 2Periodontology, ACTA-UvA, VU, Amsterdam, MOVE Research Institute

p. 19










16.10-16.20

GWAS meta-analysis for total body BMD unveils 14 new BMD loci and variants exerting age-specific effects

Carolina Medina-Gomez1,2,3 et al.

1Internal Medicine, Erasmus MC University 2The Generation R Study Group, Erasmus Medical Center, 3Department of Epidemiology, Erasmus Medical Center

p. 19










16.20-16.30

Evaluating Effect Causality of the Effect of Bone Mineral Density, Body Mass Index, Type-2 Diabetes and Chronic Heart Disease on Fracture Risk: a Mendelian Randomisation Study

Katerina Trajanoska1,2,*, Cathy Elks5,*, Charles Laurin5,*, Jack Bowden6,*, Lauren Mokry3,*, Omar Ahmad3,4,*, Stephanie Ross3,*, Hou Feng Zheng7, Ling Oei1,2, Vince Forgetta4, Dave Evans5,*, Brent Richards3,4,7,*, Fernando Rivadeneira1,2,*

1EMC, Department of Internal Medicine, 2EMC Department of Epidemiology, 3LDI, Centre for Clinical Epidemiology, 4MGU, Department of Medicine, 5UOB, Integrated Epidemiology Unite, School of Social and Community Medicine, 6CU, MRC Biostatistics Unit, 7MGU, Department of Human Genetics, *these authors contributed equally to this work

p. 20










16.30-16.50

Coffee/tea break












16.50-17.00

Mechanical loading decreases IL-1β-induced MMP-13 expression in the temporomandibular condyle

Hessam Tabeian1, Beatriz F. Betti1, Teun J. de Vries2, Frank Lobbezoo3, Vincent Everts1, Astrid D. Bakker1.

Depts of 1Oral Cell Biology, 2Periodontology, 3Oral Kinesiology, ACTA-UvA&VU, MOVE Research Institute















17.00-17.10

IL-1 receptor antagonist knockout mice: A potential model for juvenile idiopathic arthritis in the temporomandibular joint

Anouk V. ter Linde1, Astrid D. Bakker1, Teun J. de Vries2,

Frank Lobbezoo3, Peter van der Kraan4, Vincent Everts1, Hessam Tabeian1.

Depts of 1Oral Cell Biology, 2Periodontology, 3Oral Kinesiology, Academisch Centrum Tandheelkunde Amsterdam UvA&VU, MOVE Research Institute, Amsterdam.

Dept of 4Rheumatology, Radboud University Nijmegen Medical Center















17.10-17.20

Fracture Repair in the Distal Radius in Post-Menopausal Women: Follow-Up at Two Years Post-Fracture Using HRpQCT

Joost de Jong1, Frans Heyer2, Jacobus Arts3, Martijn Poeze2, Paul Willems3, Bert van Rietbergen4, Joop P.W. van den Bergh1,5,6, Piet P. Geusens1,6

1MUMC+ Rheumatology, 2MUMC+ General Surgery, 3MUMC+ Orthopedic Surgery, 4TU/e Biomedical Engineering, 5VieCuri Internal Medicine, 6UHasselt Medicine and Life Sciences













17.20-17.30

The Association Between Diabetes, Trabecular Bone Score, Bone Mineral Density and Vertebral Fractures: The Rotterdam Study

Fjorda Koromani1,2, Taulant Muka2, Ling Oei1,2, Carola Zillikens1, Albert Hofman2, Oscar Franco2, Andre G. Uitterlinden, Edwin Oei3, Didier Hans4, Fernando Rivadeneira1,2

1Department of Internal Medicine, Erasmus MC, 2Department of Epidemiology, Erasmus MC, 3Department of Radiology, Erasmus MC, 4Department of Bone & Joint, Center of Bone Diseases, Lausanne University Hospital, Lausanne, Switzerland













17.30-17.40

Autoimmune disease in patients with adult-onset sternocostoclavicular hyperostosis and first degree relatives: A Netherlands survey

Pieter Valkema1, Clare Luymes1, Janneke Witteveen1, Saskia le Cessie2,3, Natasha Appelman-Dijkstra1, Pancras Hogendoorn4, Neveen Hamdy1

1LUMC, Internal Medicine, Division Endocrinology & Centre for Bone Quality, 2LUMC, Medical Stats & Bioinformatics, 3LUMC, Clinical Epidemiology, 4LUMC, Pathology













18.15-20.00

Dinner













20.00-21.00

Business meeting




Thursday, November 19, 2015



07.30-08.50

Breakfast












08.00-08.50

Registration






SESSION III

Chair:




8:50-9.00

The fracture patient phenotype: bone and fall-related risk factors in patients at the Fracture Liaison Service

Lisanne Vranken1,2Caroline Wyers1,2, Robert van der Velde1Piet Geusens3,4Heinrich Janzing5, Wim Morrenhof6, Marcel Janssen7Joop van den Bergh1,2,4



1VieCuri, internal medicine, 2UM, internal medicine, 3MUMC, rheumatology, 4Hasselt Univ, 5VieCuri, surgery, 6VieCuri, orthopedics, 7VieCuri, clinical chemistry













09.00-09.10

Effect of postponing puberty and cross-sex hormone therapy on bone turnover markers and BMAD in transgender adolescents

Mariska Vlot1,2,3, Daniel Klink2,4, Martin den Heijer1,2, Marinus Blankenstein3, Joost Rotteveel2,4, Annemieke Heijboer3

1 VUmc, Endocrinology, 2 VUmc, Center of Expertise on Gender Dysphoria, 3 VUmc Clinical chemistry: Endocrine laboratory,4 VUmc, Paediatric Endocrinology

p.










09.10-09.20

Dissection of human mesenchymal stem cell population heterogeneity using single cell gene expression analysis

Jeroen van de Peppel, Hans van Leeuwen

Bone and Calcium research group, Internal Medicine, Erasmus MC, Rotterdam



p.










09.20-09.30

Effect of mechanical loading on the temporomandibular joint: a systematic review

Beatriz F. Betti1,2 , Astrid Bakker2 , Vincent Everts2 , Hessam Tabeian2 Frank Lobbezoo1

1 ACTA-VU, Oral Kinesiology, 2 ACTA-VU, Oral Cell Biology

p.










09.30-10.20

Key-note lecture:

The role of bone changes in the process of osteoarthritis



Prof Dr FPJG Lafeber

department Rheumatology & Clin. Immunol. UMC Utrecht














10.20-10.50

Coffee/tea break










SESSION IV

Chair:







10.50-11.00

Predicting long-term functional outcome after stable distal radius fractures: An HR-pQCT exploratory study

Frans Heyer1,2, Joost de Jong3, Paul Willems4, Jacobus Arts4, Martijn Poeze1, Piet Geusens3,5, Bert van Rietbergen6, Joop van den Bergh2,3,5

1MUMC+, General Surgery, 2VieCuri MC, Internal Medicine, 3MUMC+, Rheumatology, 4MUMC+, Orthopaedic Surgery, 5UHasselt, Life Sciences, 6TU/e, Biomedical Engineering

p.










11.00-11.10

Mechanisms Involved in Aseptic Prosthesis Loosening:

a Descriptive Systematic Review of In Vitro Studies

Angela Oostlander1, Monique Schoeman1, Jan Schoones2, Rob Nelissen1, Edward Valstar1,3

1LUMC, Orthopaedics; 2LUMC, Walaeus Library; 3TU Delft, Biomedical Engineering

p.










11.10-11.20

Extracellular matrix characterization of periprosthetic tissue: large variation in collagen content and tissue stiffness
Angela Oostlander1, Astrid Moerman2, Amir Zadpoor2, Monique Schoeman1, Rob Nelissen1, Edward Valstar1,2

1 LUMC, Orthopaedics, 2 TU Delft, Biomechanical Engineering

p.










11.20-11.30

The effect of periodontitis treatment on osteoclastogenesis

Ton Schoenmaker1, Doran Sol1, Irene Di Ciegli2, Peter van Lent2, Sergio Bizzarro1, Teun J. de Vries1

1Department of Periodontology and Oral Cell Biology, ACTA, UVA and VU Amsterdam, 2Department of Rheumatology, Radboud UMC, Nijmegen

p.










11.30-11.40

Hypothermia reduces VEGF-165 Gene Expression, but does not affect Osteogenic Differentiation of Human Adipose Mesenchymal Stem Cells under Hypoxia

Nick C. Leegwater1, Astrid D. Bakker2, Jolanda M.A. Hogervorst2, Peter A. Nolte1, Jenneke Klein-Nulend2

1Department of Orthopedics, Spaarne Gasthuis, Hoofddorp, The Netherlands

2Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Amsterdam, The Netherlands

p.








11.40-11.50

Increased Fracture Risk and Risk of Osteoporosis in Middle-aged Persons with Lower but Normal Range Serum Sodium Concentration

Chantal M. Wiepjes1,2, Renée de Mutsert2, Anna W. de Boer2,3, Natasha M.Appelman-Dijkstra4, Frits R. Rosendaal2,5, Martin den Heijer1,2

1VUmc, Endocrinology; 2LUMC, Clinical Epidemiology; 3LUMC, Public Health and Primary Care; 4LUMC Endocrinology; 5 LUMC, Thrombosis and Hemostasis

p.










11.50-12.00

Periprosthetic tissue cells produce alkaline phosphatase and mineralized matrix in response to osteogenic stimuli

Monique Schoeman1, Angela Oostlander1, Karien de Rooij1, Rob Nelissen1, Edward Valstar1,2

1 LUMC, Orthopaedics, 2 TU Delft, Biomechanical Eng.

p.










12.00-13.00

Lunch





SESSION V

Chair:




13.00-13.10

The development of a tracer technique to measure 25-Hydroxyvitamin D3 (25(OH)D3) half-life

Kerry S Jones1,2, Les J Bluck1, Shujing Ding1, Shima Assar1, Ann Prentice1,2 and Inez Schoenmakers1



1MRC Human Nutrition Research, Cambridge, UK, 2MRC Keneba, MRC Unit, Banjul, The Gambia

p.










13.10-13.20

25(OH)D3 Half-life is longer in older than younger adults

Inez Schoenmakers, Jennifer Bell, Shima Assar, Ann Prentice, Kerry S. Jones

MRC Human Nutrition Research, Cambridge, UK



p.










13.20-13.30

Effect of One Year Cross-sex Hormonal Treatment on Bone Mineral Density of the Lumbar Spine in Transgender Patients

Chantal M. Wiepjes1, Mariska C. Vlot1,2, Maartje Klaver1, Renate T. de Jongh1, Paul Lips1, Annemieke C. Heijboer2, Martin den Heijer1

1 VUmc, Internal Medicine and Center of Expertise on Gender Dysphoria 2 VUmc, Clinical Chemistry

p.










13.30-13.40

Risk factors in allogenous cortical graft surgery in fibrous dysplasia of the proximal femur

Bas Majoor1, Natasha Appelman-Dijkstra2, Neveen A.T. Hamdy2, Michiel van de Sande1, Sander Dijkstra1

Centre for Bone Quality, Leiden University Medical Centre: 1Department of Orthopaedic Surgery, 2 Department of Medicine: Division Endocrinology



p.









13.40-14.30

Key-note lecture:

The assesment of bone quality in healthy and diseased human bone



Dr B Busse

Department of Osteology and Biomechanics (IOBM)

University Medical Center Hamburg-Eppendorf, Germany













14:30-14:50

Coffee/tea break












14.50-15.00

Use of SSRIs and bone mineral density change: a population-based longitudinal study in middle-aged and elderly individuals

Annelies C. Ham1*, Nikkie Aarts1,2*, Raymond Noordam1,2, Fernando Rivadeneira1, Gijsbertus Ziere1,2, M. Carola Zillikens1, et al. *contributed equally



1Department of Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands. 2Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.

p.










15.00-15.10

Positive Effects of Vitamin D in Bone Metastases: Role for Extracellular Vesicles?

Marjolein van Driel1, Resti Rudjito1, Iris Robbesom1, Hideki Chiba2, Hans van Leeuwen1

1Department of Internal medicine, Erasmus MC, Rotterdam

2Department of Basic Pathology, Fukushima Medical University, Fukushima, Japan














15.10-15.25

Awards













15.25-15.30

Adjournment
































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